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A modern 300-acre campus with room for growth, USI is located in southwestern Indiana on Highway 62 west of Evansville, a metropolitan area with a population of 293,000. Evansville is Indiana's third largest city featuring the core of cultural, economic, financial, medical, and recreational life in southwestern Indiana. Evansville is less than 200 miles away from four major U.S. cities (176 miles southwest of Indianapolis, Indiana; 156 miles north of Nashville, Tennessee; 126 miles west of Louisville, Kentucky; and 174 miles east of St. Louis, Missouri. It is located near to both the Illinois and Kentucky state lines.

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